Mª Jesus Tunon Gonzalez

Mª JESUS TUÑON-GONZALEZ
Contact information

Phone: 34 87 291261
Fax: 34 87 291267
E-mail: dfimtg@unileon.es

Current research interests

Hepatology

Academic education and postgraduate training

1971-1976. Biology, University of Leon, Spain.
1985. Doctoral Thesis (Ph.D). University of Leon, Spain.

Employment positions

1977-1989. Assistant Lecturer, Department of Physiology, Pharmacology and Toxicology, University of Leon, Spain.
1990-2003. Senior Lecturer, Department of Physiology, University of Leon, Spain.
1998-present. Vice-Director, Department of Physiology, University of Leon, Spain
2003-present. Professor, Department of Physiology, University of Leon, Spain

Representative publications

Alterations induced by fascioliasis and cirrhosis on the biliary excretion of cefmetazole in Wistar rats. P. Lopez, L. A. Garcia-Pardo, M. J. Tunon P. Gonzalez, J. Gonzalez-Gallego. Comparative Biochemistry and Physiology: 103C, 53-56, 1992.
Effects of diabetes on disposition and hepatic handling of cefmetazole in rats. C. Barrientos, P. Gonzalez, M. J. Tunon, J. Gonzalez-Gallego. Clinical and Experimental Pharmacology and Physiology: 20, 399-404, 1993.
Ductular proliferation and hepatic secretory function in experimental fascioliasis. P. Lopez, M. J. Tunon, P. Gonzalez, N. Diez, A. M. Bravo, J. Gonzalez-Gallego. Experimental Parasitology: 73, 36-42, 1993.
Effects of experimental fasciolosis on bilirubin metabolism in the rat. P. Lopez, P. Gonzalez, M. J. Tunon, J. Gonzalez-Gallego. Experimental Parasitology: 78, 386-393, 1994.
Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver. S. Sanchez-Campos, M. J. Tunon, P. Gonzalez, R. Campo, M. C. Ferreras, Y. Manga, J. Gonzalez-Gallego. Comparative Biochemistry and Physiology: 115, 55-60, 1996.
Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. S. Sanchez-Campos, R. Lopez-Acebo, P. González, J. M. Culebras, M. J. Tunon, J. Gonzalez-Gallego. Transplantation: 66-84-88, 1998.
Role of colchicine-sensitive bile acid secretion in enhanced bile formation induced by experimental dicrocoeliosis in the hamster. S. Sanchez-Campos, M. J. Tuñon, P. Gonzalez, J. J. G. Marin, J. Gonzalez-Gallego. Life Sciences: 63, 1963-1974, 1998.
Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicrocoeliosis in hamsters. S. Sanchez-Campos, M. J. Tuñon, P. Gonzalez, J. Gonzalez-Gallego. Parasitology Research: 85, 468-474, 1999.
Liver flow changes during laparoscopic surgery in pigs: a study of hepatic indocyanine green removal. M. J. Tuñon, P. Gonzalez, F. Jorquera, A. Llorente, M. Gonzalo-Orden, J. Gonzalez-Gallego. Surgical Endoscopy: 13, 668-672, 1999.
Effects of parenteral nutrition supplemented with glutamine or glutamine dipeptides on liver detoxication systems in rats. B. Matilla, J. Ortiz, P. González, F. García-Diez, J. M.Culebras, F. Jorquera, J. González-Gallego, M. J. Tuñón. Nutrition: 16, 125-128, 2000.
Morphologic and biochemical changes caused by experimentally induced dicroceliosis in hamsters (Mesocricetus auratus). S. Sánchez-Campos, P. González, C. Ferreras., MJ García-Iglesias, J González-Gallego, MJ Tuñon. Comparative Medicine 50, 147-152, 2000.
Hepatoprotective effects of the flavonoid quercetin in rats with biliary obstruction. W. Peres, M. J. Tuñón, S. Mato, P. S. Collado, J. González-Gallego. Journal of Hepatology: 33,742-750, 2000.
Effects of aging on the suceptibility to the toxic effects of cyclosporin in rats: Changes in liver glutathione and antioxidant enzymes. J. Palomero, A. I. Galán, M. E. Muñoz, M. J. Tuñón, J. González-Gallego, R. Jiménez. Free Radical Biology & Medicine: 30, 836-845, 2001.
Choleresis and inhibition of biliary lipid secretion induced by piperacillin. P. González, J. L. Mauriz, R. Jiménez, J. González-Gallego y M. J. Tuñón. Clinical and Experimental Physiology and Pharmacology: 20, 880-884, 2002.
Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. A. Pavanato, M. J. Tuñón, S. Sánchez-Campos, CS. Llesuy, J. González-Gallego, N. Marroni. Digestive Diseases and Sciences: 48, 824-829, 2003.
Rabbit hemorrhagic viral disease: characterization of a new animal model of fulminant hepatic failure.S. Sánchez-Campos, J. Garcia-Ferreras, M. Alvarez, F. Jorquera, M. J. Tuñón, J. González-Gallego. Journal of Laboratory and Clinical Medicine: 141, 272-278, 2003.
Diagnostic imaging in hepatic fascioliasis: ultrasound, computer tomography and magnetic resonance findings. M. Gonzalo-Orden, L. Millán, S. Sánchez-Campos, R. Jiménez, J. González-Gallego, M. J. Tuñón. Parasitology Research: 90, 359-364, 2003.
Effects of aging and cyclosporin treatment on the hepatobiliary efflux of gtlutathione. J. Palomero, A. I. Galán, M. E. Muñoz, M. J. Tuñón, J. González-Gallego, R. Jiménez. Life Sciences: 73, 3387-3397, 2003.
Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappaB activation in rat hepatocytes. M. J. Tuñón, S. Sánchez-Campos, B. Gutierrez, J. González-Gallego. Biochemical Pharmacology: 66, 439-445, 2003.
Effects of S-adenosylmethionine on intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat. J. Palomero, A. I. Galán, M. E. Munoz, J. González-Gallego, M. J. Tuñón, R. Jiménez Toxicology: 200, 21-27, 2004.
Pathogenic molecular mechanisms in an animal model of fulminant hepatic failure: rabbit hemorrhagic viral disease. S. Sánchez-Campos, J. M. Culebras, M. Alvarez, Javier González-Gallego, M. J. Tuñón. Journal of Laboratory and Clinical Medicine: 144, 215-222, 2004.
Quercetin attenuates nuclear factor-kB activation and nitric oxide production in interleukin-1ß–activated rat hepatocytes. S. Martínez-Flórez, B. Gutiérrez-Fernández, S. Sánchez-Campos, J. González-Gallego, M.J. Tuñón. Journal of Nutrition: 135, 1359-1365, 2005.
Effects of parenteral nutrition supplemented with alanyl-glutamine on nutrition status in rats. J. J. Ortíz de Urbina, F. Jorquera, J. M. Culebras, C.Villares, J. González-Gallego, M.J. Tuñón. Journal of Parenteral and Enteral Nutrition: 29, 262-265, 2005.
Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-kB activation or iNOS expression. M. B. Gutierrez, C. Villares, M. J. Tuñón, J. González-Gallego. Toxicology: 222, 125-131, 2006.

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Effects of parenteral nutrition supplemented with alanyl-glutamine on nutrition status in rats. J. J. Ortíz de Urbina, F. Jorquera, J. M. Culebras, C.Villares, J. González-Gallego, M.J. Tuñón. Journal of Parenteral and Enteral Nutrition: 29, 262-265, 2005.