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Abstract
A comparison of the pharmacokinetic profiles of netobimin (NTB), albendazole
sulfoxide (ABZSO) and albendazole sulfone (ABZSO2) was performed in gerbils
(Meriones unguiculatus) with intra-abdominal hydatidosis and in healthy
gerbils. The infection was developed after peritoneal
inoculation of protoscolices of Echinococcus granulosus from sheep.
Plasma concentrations of NTB, ABZSO and ABZSO2 were measured by HPLC after
oral administration of 50 mg NTB kg-1. The results showed an incomplete
biotransformation of NTB over the experimental time; and this increased
in infected animals. ABZSO and ABZSO2 pharmacokinetic profiles were unaffected
and were similar in both non-infected and infected animals. Both hepatic
and intestinal microsomal sulfoxidase activities were measured. Since infected
gerbils induced hepatic activity and decreased intestinal activity, the
total activity was not different in infected and non-infected animals.
In summary, intra-abdominal hydatid disease affected the pharmacokinetic
profile of NTB, but ABZSO and ABZSO2 plasma concentrations were not different
in infected and non-infected gerbils.